methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride

Base Information

• Chemical Name: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride
• CAS No.: 197979-67-2
• Molecular Formula: C₂₇H₃₃N₃O₅*ClH
• Molecular Weight: 516.037

Synonyms:methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride

Chemical Property of methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride

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Technology Process of methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride

There total 3 articles about methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride (197979-67-2)

Guidance literature:

Reference yield: 64.0%

N-amino-N'-methylpiperazine (6928-85-4) + 2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester (197979-64-9) → methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride (197979-67-2)

Guidance literature:

2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

N-amino-N'-methylpiperazine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol; water; at 20 ℃;

DOI:10.1021/op9000719

Reference yield:

methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate (197979-66-1) → methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate hydrochloride (197979-67-2)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2008.10.067

upstream raw materials:

methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl]-2-butenoate

N-amino-N'-methylpiperazine

2-[1-(3',5'-dimethoxyphenyl)-ethylidene]-3-[1-phenyl-(E)-methylidene]-succinic acid 1-methyl ester

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