3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide

Base Information

• Chemical Name: 3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide
• CAS No.: 861146-15-8
• Molecular Formula: C₉H₇BrN₄O₂
• Molecular Weight: 283.084
• Mol file: 861146-15-8.mol

Synonyms:3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide

Chemical Property of 3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide

There total 3 articles about 3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(4-bromophenyl)-1,2,4-oxadiazole-5-carboxylate (861146-12-5) → 3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide (861146-15-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; cooling;

DOI:10.1515/HC.2005.11.1.29

Reference yield:

p-bromobenzamidoxime (19227-14-6,69113-23-1) → 3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide (861146-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 4.5 h / Heating

2: NH₂-NH₂*H₂O / ethanol / 2 h / cooling

With hydrazine hydrate; In tetrahydrofuran; ethanol;

DOI:10.1515/HC.2005.11.1.29

Reference yield:

4-bromobenzenecarbonitrile (623-00-7) → 3-(4-bromo-phenyl)-[1,2,4]oxadiazole-5-carboxylic acid hydrazide (861146-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium carbonate / water; methanol / 4 h / Reflux

2: tetrahydrofuran / 4.5 h / Reflux

3: hydrazine hydrate / ethanol / 2 h / 0 °C

With hydrazine hydrate; hydroxylamine hydrochloride; sodium carbonate; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1016/j.bmc.2012.08.047

upstream raw materials:

methyl 3-(4-bromophenyl)-1,2,4-oxadiazole-5-carboxylate

p-bromobenzamidoxime

4-bromobenzenecarbonitrile

Downstream raw materials:

5-[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]-2-(N-phenylamino)-1,3,4-oxadiazole

N₁-[3-(4-bromophenyl)-1,2,4-oxadiazol-5-ylcarbonyl]-N₄-phenyl thiosemicarbazide