(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

Base Information

Chemical Name:(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate
CAS No.:124605-43-2
Molecular Formula:C₁₇H₁₈O₆S
Molecular Weight:350.392
Hs Code.:

Synonyms:(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

Chemical Property:

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Technology Process of (2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

There total 3 articles about (2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 124649-67-8
methyl (2S,3R)-3-phenyl-2,3-dihydroxypropanoate

: 98-59-9
p-toluenesulfonyl chloride

: 124605-43-2
(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 63h;
DOI:10.1021/jo00293a052

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 124605-43-2
(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / t-BuOH / H2O / 18 h / Ambient temperature; Sharpless AD process (AD-β)

2: Et₃N / CH₂Cl₂ / 38 h / 0 °C

With triethylamine; tert-butyl alcohol; In dichloromethane; water;
DOI:10.1016/S0040-4039(98)01124-1

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 124605-43-2
(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / AD-mix-β / 2-methyl-propan-2-ol; H2O / 18 h / Ambient temperature

2: triethylamine / CH₂Cl₂ / 38 h / 0 °C

With AD-mix-β; triethylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(98)01108-9