1-(3-chlorophenyl)isoquinoline

Base Information

• Chemical Name: 1-(3-chlorophenyl)isoquinoline
• CAS No.: 777097-56-0
• Molecular Formula: C₁₅H₁₀ClN
• Molecular Weight: 239.704
• Mol file: 777097-56-0.mol

Synonyms:1-(3-chlorophenyl)isoquinoline

Chemical Property of 1-(3-chlorophenyl)isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-chlorophenyl)isoquinoline

There total 1 articles about 1-(3-chlorophenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.6%

isoquinoline (119-65-3) + 3-chloro-aniline (108-42-9) → 1-(3-chlorophenyl)isoquinoline (777097-56-0)

Guidance literature:

3-chloro-aniline; With boron trifluoride diethyl etherate; isopentyl nitrite; In tetrahydrofuran; at -5 ℃; for 0.5h; Inert atmosphere;

isoquinoline; With titanium(IV) oxide; trifluoroacetic acid; In N,N-dimethyl acetamide; for 48h; Irradiation; Inert atmosphere;

DOI:10.1016/j.mcat.2019.04.017

Reference yield: 67.0%

1-(3-chlorophenyl)isoquinoline (777097-56-0) → 1-(3-chloro-2-iodophenyl)isoquinoline

Guidance literature:

1-(3-chlorophenyl)isoquinoline; With n-butyllithium; In tetrahydrofuran; at -75 ℃; for 1h;

With iodine; In tetrahydrofuran;

DOI:10.1021/jo049454v

Reference yield: 58.0%

aniline (62-53-3) + 1-(3-chlorophenyl)isoquinoline (777097-56-0) → 3-(isoquinolin-1-yl)-N-phenylaniline (1325592-71-9)

Guidance literature:

With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In toluene; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/ic200794b

upstream raw materials:

isoquinoline

3-chloro-aniline

Downstream raw materials:

3-(isoquinolin-1-yl)-N-phenylaniline

N-(3-(isoquinolin-1-yl)phenyl)-N-phenylpyridin-2-amine