2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate

Base Information

Chemical Name:2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate
CAS No.:910864-40-3
Molecular Formula:C₅₃H₇₁O₁₁PSi₂
Molecular Weight:971.285
Hs Code.:

Synonyms:2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate

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Chemical Property of 2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate

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Technology Process of 2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate

There total 6 articles about 2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 910864-23-2
2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-3-diphenyl phosphate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 910864-40-3
2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 50 ℃; for 48h;
DOI:10.1021/jo0610816

Reference yield:

: 2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol-1,3,5-O-orthoformate

: 910864-40-3
2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / aq. HCl / methanol / 18 h / 20 °C

2: 53 percent / Et₃N / BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe / toluene

3: 90 percent / imidazole / dimethylformamide / 48 h / 50 °C

With 1H-imidazole; hydrogenchloride; triethylamine; BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0610816

Reference yield:

: 910864-22-1
2-O-benzyl-4,6-di-O-p-methoxybenzyl-D-myo-inositol

: 910864-40-3
2-O-benzyl-4,6-di-O-p-methoxybenzyl-1,5-di-O-tert-butyldimethylsilyl-D-myo-inositol-3-diphenyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / Et₃N / BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe / toluene

2: 90 percent / imidazole / dimethylformamide / 48 h / 50 °C

With 1H-imidazole; triethylamine; BocHis(Me)-[4S-tBuOPro]-[(CH₂)4-1,4-diylGly]-Tyr(tBu)-PheOMe; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0610816