N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide

Base Information

Chemical Name:N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide
CAS No.:1443255-18-2
Molecular Formula:C₂₉H₂₂Cl₂F₃N₃O₄
Molecular Weight:604.413
Hs Code.:

Synonyms:N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide

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Chemical Property of N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide

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Technology Process of N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide

There total 7 articles about N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 453-20-3,84921-89-1,864447-89-2
3-Hydroxytetrahydrofuran

: 1443255-04-6
N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(chloromethyl)benzamide

: 1443255-18-2
N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide

Guidance literature:: With potassium tert-butylate; N,N-dimethyl-formamide; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1441141-76-9
1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole

: 1443255-18-2
N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide; acetic acid / 0.25 h / 150 °C / Microwave irradiation

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - 0 °C

2.2: 2 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4.1: iron; acetic acid / water / 2 h / 50 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C

6.1: potassium tert-butylate; N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

With N-iodo-succinimide; potassium tert-butylate; isopropylmagnesium chloride; iron; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1441141-81-6
(5-chloro-2-nitro-phenyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol

: 1443255-18-2
N-[4-chloro-2-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazole-4-carbonyl]phenyl]-3-(tetrahydrofuran-3-yloxymethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

2: iron; acetic acid / water / 2 h / 50 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C

4: potassium tert-butylate; N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

With potassium tert-butylate; iron; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; water;