2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine

Base Information

Chemical Name:2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine
CAS No.:946000-44-8
Molecular Formula:C₁₅H₂₆ClNOSi
Molecular Weight:299.916
Hs Code.:

Synonyms:2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine

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Chemical Property of 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine

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Technology Process of 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine

There total 5 articles about 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 946000-42-6
tert-butyl-[2-chloro-5-(2-nitro-vinyl)-benzyloxy]-dimethyl-silane

: 946000-44-8
2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine

Guidance literature:: tert-butyl-[2-chloro-5-(2-nitro-vinyl)-benzyloxy]-dimethyl-silane; With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;

With Rochelle's salt; In diethyl ether; for 1h;

Reference yield:

: 873782-26-4
((5-bromo-2-chlorobenzyl)oxy)(tert-butyl)dimethylsilane

: 946000-44-8
2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: ammonium acetate / acetic acid / 3 h / Heating / reflux

3.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 0 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

4.2: 1 h

With 1H-imidazole; ammonium acetate; lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: C₉H₈ClNO₃

: 946000-44-8
2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 0 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

2.2: 1 h

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;