1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline

Base Information

• Chemical Name: 1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline
• CAS No.: 182515-09-9
• Molecular Formula: C₂₀H₂₃NO₄S
• Molecular Weight: 373.473
• Mol file: 182515-09-9.mol

Synonyms:1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline

Chemical Property of 1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline

There total 1 articles about 1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

p-toluenesulfonyl fluoride (455-16-3) + 1-(tert-butoxycarbonyl)indoline (143262-10-6) → 1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline (182515-09-9)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; 1.) -78 deg C, 120 min, 2.) -78 deg C, 30 min;

DOI:10.1039/p19960000675

Reference yield: 70.0%

1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline (182515-09-9) → 7-<(4-Methylphenyl)sulfonyl>indoline (177265-07-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 40 - 50 ℃;

DOI:10.1039/p19960000675

Reference yield:

1-(tert-Butoxycarbonyl)-7-<(4-methylphenyl)sulfonyl>indoline (182515-09-9) → N-(3-Bromopropionyl)-7-<(4-methylphenyl)sulfonyl>indoline (177265-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / aq. HCl / tetrahydrofuran / 40 - 50 °C

2: 77 percent / DMAP, Et₃N / dimethylformamide

With hydrogenchloride; dmap; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/p19960000675

upstream raw materials:

p-toluenesulfonyl fluoride

1-(tert-butoxycarbonyl)indoline

Downstream raw materials:

7-<(4-Methylphenyl)sulfonyl>indoline

pyroquilone

N-(3-Bromopropionyl)-7-<(4-methylphenyl)sulfonyl>indoline