5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

Base Information

Chemical Name:5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one
CAS No.:1104451-76-4
Molecular Formula:C₂₅H₃₀N₄O₄S
Molecular Weight:482.604
Hs Code.:

Synonyms:5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

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Chemical Property of 5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

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Technology Process of 5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

There total 6 articles about 5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1104449-68-4
5-methyl 1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

: 219555-98-3
2-chloro-5-propylpyrimidine

: 1104451-76-4
5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

Guidance literature:: 5-methyl 1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one; 2-chloro-5-propylpyrimidine; With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2.5h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In ethanol; hexane; water; at 20 ℃; for 16h; Inert atmosphere; Reflux;
DOI:10.1021/jm501175v

Reference yield:

: 199103-19-0
benzyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate

: 1104451-76-4
5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere

2.1: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

4.2: 16 h / 20 °C / Inert atmosphere; Reflux

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v

Reference yield:

: 95798-23-5
1-(benzyloxycarbonyl)-4-hydroxypiperidine

: 1104451-76-4
5-methyl-1-(4-(methylsulfonyl)phenyl)-4-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)oxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 100 °C / Inert atmosphere

3.1: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / Inert atmosphere; Sealed tube

5.2: 16 h / 20 °C / Inert atmosphere; Reflux

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v