ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Base Information

Chemical Name:ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate
CAS No.:146624-66-0
Molecular Formula:C₃₆H₄₃N₃O₅Si
Molecular Weight:625.84
Hs Code.:

ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Synonyms:ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

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Chemical Property of ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

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Technology Process of ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

There total 12 articles about ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 146624-49-9
ethyl 1-<<3-bromo-2-<2-<<(1,1-dimethylethoxy)carbonyl>amino>phenyl>-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

: 1066-54-2
trimethylsilylacetylene

: 146624-66-0
ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; at 90 ℃; for 29h;
DOI:10.1021/jm00045a016

Reference yield:

: 1025993-01-4
3-Cyclopropyl-2-nitro-3-oxo-propionic acid ethyl ester

: 146624-66-0
ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

2: 24 percent / Et₃N / ethanol

3: 62 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

4: 32 percent / bis(triphenylphosphine)palladium dichloride, CuI, diethylamine / 29 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; potassium carbonate; diethylamine; triethylamine; acetyl chloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: 24922-02-9
Ethyl 3-cyclopropyl-3-oxopropionate

: 146624-66-0
ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-<(trimethylsilyl)ethynyl>-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / aq. NaNO₂ / acetic acid / 4 h / Ambient temperature

2: 60 percent / H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: 24 percent / Et₃N / ethanol

4: 62 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

5: 32 percent / bis(triphenylphosphine)palladium dichloride, CuI, diethylamine / 29 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; potassium carbonate; diethylamine; triethylamine; acetyl chloride; sodium nitrite; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016