4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile

Base Information

Chemical Name:4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile
CAS No.:1428330-60-2
Molecular Formula:C₁₉H₁₈Cl₂N₂O₄S
Molecular Weight:441.335
Hs Code.:

Synonyms:4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile

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Chemical Property of 4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile

Chemical Property:

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Technology Process of 4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile

There total 3 articles about 4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 4-(4-hydroxypiperidin-4-ylmethoxy)benzonitrile trifluoroacetate

: 16271-33-3
2,4-Dichlorobenzenesulfonyl chloride

: 1428330-60-2
4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃;
DOI:10.1039/c2md20259j

Reference yield:

: 767-00-0
4-cyanophenol

: 1428330-60-2
4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / isopropyl alcohol; water; dimethyl sulfoxide / 2.5 h / 80 °C

2: dichloromethane / 2 h / 25 °C

3: triethylamine / dichloromethane / 0 - 25 °C

With caesium carbonate; triethylamine; In dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1039/c2md20259j

Reference yield:

: 147804-30-6
1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

: 1428330-60-2
4-[1-(2,4-dichlorobenzenesulfonyl)-4-hydroxypiperidin-4-ylmethoxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / isopropyl alcohol; water; dimethyl sulfoxide / 2.5 h / 80 °C

2: dichloromethane / 2 h / 25 °C

3: triethylamine / dichloromethane / 0 - 25 °C

With caesium carbonate; triethylamine; In dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1039/c2md20259j