(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

Base Information

Chemical Name:(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide
CAS No.:1369704-76-6
Molecular Formula:C₁₅H₂₃NO₄S
Molecular Weight:313.418
Hs Code.:

Synonyms:(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

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Chemical Property of (R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

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Technology Process of (R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

There total 6 articles about (R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1369704-61-9
(R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate

: 1369704-76-6
(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

Guidance literature:: With hydrogenchloride; In methanol; at 85 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm201628y

Reference yield:

: (S)-N-((R)-1-(3-(cyclopropylmethoxy)phenyl)ethyl)-2-methylpropane-2-sulfinamide

: 1369704-76-6
(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: sodium iodide / N,N-dimethyl-formamide / 6 h / 20 - 90 °C / Inert atmosphere

4: hydrogenchloride / methanol / 1 h / 85 °C / Inert atmosphere

With hydrogenchloride; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201628y

Reference yield:

: (S,E)-N-(3-(cyclopropylmethoxy)benzylidene)-2-methylpropane-2-sulfinamide

: 1369704-76-6
(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / N,N-dimethyl-formamide / 6 h / 20 - 90 °C / Inert atmosphere

5: hydrogenchloride / methanol / 1 h / 85 °C / Inert atmosphere

With hydrogenchloride; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201628y