(R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate

Base Information

• Chemical Name: (R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate
• CAS No.: 1369704-61-9
• Molecular Formula: C₁₇H₂₅NO₅S
• Molecular Weight: 355.455
• Mol file: 1369704-61-9.mol

Synonyms:(R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate

Chemical Property of (R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate

There total 5 articles about (R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(R)-3-chloro-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)propane-1-sulfonamide (1369704-46-0) + sodium acetate (127-09-3) → (R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate (1369704-61-9)

Guidance literature:

With sodium iodide; In N,N-dimethyl-formamide; at 20 - 90 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jm201628y

Reference yield:

(S)-N-((R)-1-(3-(cyclopropylmethoxy)phenyl)ethyl)-2-methylpropane-2-sulfinamide → (R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate (1369704-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: sodium iodide / N,N-dimethyl-formamide / 6 h / 20 - 90 °C / Inert atmosphere

With hydrogenchloride; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm201628y

Reference yield:

(S,E)-N-(3-(cyclopropylmethoxy)benzylidene)-2-methylpropane-2-sulfinamide → (R)-3-(N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)sulfamoyl)propyl acetate (1369704-61-9)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran; diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / N,N-dimethyl-formamide / 6 h / 20 - 90 °C / Inert atmosphere

With hydrogenchloride; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm201628y

upstream raw materials:

(R)-1-(3-(cyclopropylmethoxy)phenyl)ethanamine hydrochloride

(R)-3-chloro-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)propane-1-sulfonamide

sodium acetate

3-(cyclopropylmethoxy)benzaldehyde

Downstream raw materials:

(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-hydroxypropane-1-sulfonamide

(R)-N-(1-(3-(cyclopropylmethoxy)Phenyl)ethyl)-3-(methoxymethoxy)propane-1-sulfonamide

(R)-N-(1-(3-(cyclopropylmethoxy)phenyl)ethyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide