6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal

Base Information

Chemical Name:6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal
CAS No.:536753-42-1
Molecular Formula:C₂₆H₃₆N₄O₅
Molecular Weight:484.596
Hs Code.:

Synonyms:6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal

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Chemical Property of 6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal

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Technology Process of 6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal

There total 11 articles about 6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (5S,11S,13aR)-5-Benzyl-11-((R)-6,7-dihydroxy-octyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

: 536753-42-1
6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal

Guidance literature:: With sodium periodate; In methanol; water; at 20 ℃; for 1h;
DOI:10.1016/S0031-9422(02)00685-4

Reference yield: 90.0%

: 887277-69-2
(5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

: 536753-42-1
6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal

Guidance literature:: With sodium periodate; In tetrahydrofuran; water; for 1h;
DOI:10.1016/j.bmc.2005.12.063

Reference yield:

: 887277-60-3
Boc-L-Ae₉-Aib-L-Phe-D-Pro-OtBu

: 536753-42-1
6-((5S,11S,13aR)-5-Benzyl-8,8-dimethyl-4,7,10,13-tetraoxo-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanal

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 3 h / 0 °C

2: 87 percent / [O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium]PF₆; DIEA / dimethylformamide / 3 h

3: 100 percent / 4-methylmorpholine-N-oxide; water / microencapsulated osmium tetroxide / acetone; acetonitrile / 18 h

4: 90 percent / sodium periodate / tetrahydrofuran; H₂O / 1 h

With sodium periodate; water; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; osmium(VIII) oxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmc.2005.12.063