(5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

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Chemical Name:(5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone
CAS No.:887277-69-2
Molecular Formula:C₂₇H₄₀N₄O₆
Molecular Weight:516.638
Hs Code.:

Synonyms:(5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

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Chemical Property of (5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

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Technology Process of (5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

There total 9 articles about (5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 887277-64-7
cyclo(-L-Ae₉-Aib-L-Phe-D-Pro-)

: 887277-69-2
(5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Guidance literature:: With water; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In acetone; acetonitrile; for 18h;
DOI:10.1016/j.bmc.2005.12.063

Reference yield:

: 887277-60-3
Boc-L-Ae₉-Aib-L-Phe-D-Pro-OtBu

: 887277-69-2
(5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 3 h / 0 °C

2: 87 percent / [O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium]PF₆; DIEA / dimethylformamide / 3 h

3: 100 percent / 4-methylmorpholine-N-oxide; water / microencapsulated osmium tetroxide / acetone; acetonitrile / 18 h

With water; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; osmium(VIII) oxide; In N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmc.2005.12.063

Reference yield:

: (R)-1-{(S)-2-[2-((S)-2-Amino-non-8-enoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid; compound with trifluoro-acetic acid

: 887277-69-2
(5S,11S,13aR)-5-Benzyl-11-(6,7-dihydroxy-heptyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / [O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium]PF₆; DIEA / dimethylformamide / 3 h

2: 100 percent / 4-methylmorpholine-N-oxide; water / microencapsulated osmium tetroxide / acetone; acetonitrile / 18 h

With water; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; osmium(VIII) oxide; In N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmc.2005.12.063