(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

Base Information

Chemical Name:(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt
CAS No.:1335138-89-0
Molecular Formula:C₇H₈O₃S*C₁₆H₂₇N₃O₂
Molecular Weight:465.614
Hs Code.:

Synonyms:(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

Suppliers and Price of (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

There total 14 articles about (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: (2S)-5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

: 104-15-4
toluene-4-sulfonic acid

: 1335138-89-0
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

Guidance literature:: In tetrahydrofuran; water; for 7h; Reflux;

Reference yield:

: 1335138-62-9
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

: 104-15-4
toluene-4-sulfonic acid

: 1335138-89-0
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

: 2523-55-9
trans-4-methylcyclohexanamine

: 1335138-89-0
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid p-toluenesulfonate salt

Guidance literature:: Multi-step reaction with 8 steps

1: 4 h / 70 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3: sodium hydrogencarbonate; iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; toluene / 2 h / 20 °C

4: piperidine; propionic acid / cyclohexane / 48 h / Reflux

5: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

6: CHIRALPAK IA / ethanol; hexane / Resolution of racemate

7: water; hydrogenchloride / 4 h / Reflux

8: tetrahydrofuran / 24 h / 20 °C

With piperidine; hydrogenchloride; lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; water; hydrogen; iodine; sodium hydrogencarbonate; propionic acid; In tetrahydrofuran; ethanol; hexane; cyclohexane; water; toluene; 4: |Knoevenagel Condensation;