6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

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Chemical Name:6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one
CAS No.:1360055-26-0
Molecular Formula:C₃₁H₃₁FN₆O₆S
Molecular Weight:634.688
Hs Code.:

6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Synonyms:6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

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Chemical Property of 6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

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Technology Process of 6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

There total 9 articles about 6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1360055-25-9
6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethylsulfanyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

: 1360055-26-0
6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Guidance literature:: 6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethylsulfanyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one; With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;

With sodium hydroxide; In dichloromethane;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1360055-26-0
6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1.75 h / -78 °C

1.3: -78 - 25 °C

2.1: N-ethyl-N,N-diisopropylamine / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 17 h / 110 °C / Inert atmosphere

3.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 17 h / 100 °C / Inert atmosphere

4.1: lithium hydroxide / 1,4-dioxane / 17 h / 25 °C / Inert atmosphere

5.1: trifluoroacetic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C

With n-butyllithium; caesium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

Reference yield:

: 183311-60-6
5-bromo-2-(2,2,5,5-tetramethyl-1,2,5-azadisilolidin-1-yl)pyridine

: 1360055-26-0
6-tert-Butyl-8-fluoro-2-(3-{5-[5-(2-hydroxy-ethanesulfonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 17 h / 110 °C / Inert atmosphere

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 17 h / 100 °C / Inert atmosphere

3: lithium hydroxide / 1,4-dioxane / 17 h / 25 °C / Inert atmosphere

4: trifluoroacetic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;