α-hydroxy-3,5-difluoroacetophenone

Base Information

Chemical Name:α-hydroxy-3,5-difluoroacetophenone
CAS No.:1260403-62-0
Molecular Formula:C₈H₆F₂O₂
Molecular Weight:172.131
Hs Code.:

Synonyms:α-hydroxy-3,5-difluoroacetophenone

Suppliers and Price of α-hydroxy-3,5-difluoroacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of α-hydroxy-3,5-difluoroacetophenone

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of α-hydroxy-3,5-difluoroacetophenone

There total 4 articles about α-hydroxy-3,5-difluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1260403-63-1
α-acetoxy-3,5-difluoroacetophenone

: 1260403-62-0
α-hydroxy-3,5-difluoroacetophenone

Guidance literature:: With hydrogenchloride; water; In methanol; at 40 ℃; Inert atmosphere;
DOI:10.1021/jo3005556

Reference yield: 60.0%

: 461-96-1
3,5-difluorobromobenzene

: 13831-31-7
Acetoxyacetyl chloride

: 1260403-62-0
α-hydroxy-3,5-difluoroacetophenone

Guidance literature:: 3,5-difluorobromobenzene; With isopropylmagnesium chloride; at 40 ℃;

Acetoxyacetyl chloride; With copper(l) chloride;

With hydrogenchloride; In methanol; water; at 40 ℃;
DOI:10.1021/op400150w

Reference yield:

: 461-96-1
3,5-difluorobromobenzene

: 1260403-62-0
α-hydroxy-3,5-difluoroacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / 40 - 45 °C / Inert atmosphere

1.2: 4 h / -10 °C / Inert atmosphere

1.3: 0 - 10 °C / Inert atmosphere

2.1: hydrogenchloride; water / methanol / 5 h / 40 - 45 °C / Inert atmosphere

With hydrogenchloride; water; isopropylmagnesium chloride; In tetrahydrofuran; methanol;