1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid

Base Information

Chemical Name:1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid
CAS No.:1372544-52-9
Molecular Formula:C₂₇H₃₄N₆O₃S
Molecular Weight:522.671
Hs Code.:

Synonyms:1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid

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Chemical Property of 1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid

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Technology Process of 1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid

There total 14 articles about 1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1372548-42-9
ethyl 1-[5-[7-cyclohexyl-2-(ethylcarbamoylamino)-1,3-benzothiazol-5-yl]pyrimidin-2-yl]-4-methyl-piperidine-4-carboxylate

: 1372544-52-9
1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid

Guidance literature:: ethyl 1-[5-[7-cyclohexyl-2-(ethylcarbamoylamino)-1,3-benzothiazol-5-yl]pyrimidin-2-yl]-4-methyl-piperidine-4-carboxylate; With water; sodium hydroxide; In ethanol; at 120 ℃; for 0.5h; microwave irradiation;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 97-02-9
2,4-Dinitroanilin

: 1372544-52-9
1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: bromine; acetic acid / water / 2 h / 100 °C

1.2: 20 °C / pH 8 - 10

2.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 70 °C / Inert atmosphere

3.1: methanol / 16 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; iron / ethanol; water / 0.75 h / 80 °C / Industry scale

4.2: pH 8 - 10 / Industry scale

5.1: tert.-butylnitrite; boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 0.5 h / -5 - 0 °C

6.1: 1,4-dioxane / 80 °C / Inert atmosphere

7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; methanol / 5 h / 80 °C / Inert atmosphere

8.1: lithium chloride; zinc(II) chloride / tetrahydrofuran; diethyl ether / 0.25 h / 20 °C

8.2: 0.5 h / 110 °C / microwave irradiation

9.1: water; sodium hydroxide / ethanol / 0.5 h / 120 °C / microwave irradiation

With hydrogenchloride; potassium phosphate; tert.-butylnitrite; boron trifluoride diethyl etherate; water; bromine; iron; acetic acid; lithium chloride; sodium hydroxide; copper(ll) bromide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water; acetonitrile;

Reference yield:

: 189442-87-3
ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate

: 1372544-52-9
1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / 70 °C

3.1: potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; methanol / 5 h / 80 °C / Inert atmosphere

5.1: lithium chloride; zinc(II) chloride / tetrahydrofuran; diethyl ether / 0.25 h / 20 °C

5.2: 0.5 h / 110 °C / microwave irradiation

6.1: water; sodium hydroxide / ethanol / 0.5 h / 120 °C / microwave irradiation

With hydrogenchloride; potassium phosphate; water; potassium acetate; N-ethyl-N,N-diisopropylamine; lithium chloride; sodium hydroxide; zinc(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol;