189442-87-3

Basic information

• Product Name: Ethyl N-Boc-4-methylpiperidine-4-carboxylate
• Synonyms: ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOX&;1,4-PIPERIDINEDICARBOXYLIC ACID, 4-1-(1,1-DIMETHYL;N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLATEN-BOC-4-METHYL ISONIPECOTIC ACID ETHYL ESTER;1-TERT-BUTYL 4-METHYL 4- METHYLPIPERIDINE1,4-DICARBOXYLATE;N-Boc-4-Methyl isonipecotic acid ethyl ester ,95%;Ethyl N-Boc-4-methylpiperidine-4-carboxylate ,97%;1-tert-butyl 4-ethyl 4-Methylpiperidine-1,4-dicarboxylate;1-Boc-4-Methyl-isonipecotic acid ethyl ester
• CAS NO: 189442-87-3
• Molecular Formula: C₁₄H₂₅NO₄
• Molecular Weight: 271.35
• Product Categories: Amino Acids and Derivatives;Heterocycles;API intermediates;Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 189442-87-3.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 329.651 °C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.0134
• Vapor Pressure: 0.000175mmHg at 25°C
• Refractive Index: 1.4554
• Storage Temp.: 2-8°C
• PKA: -2.20±0.40(Predicted)
• CAS DataBase Reference: Ethyl N-Boc-4-methylpiperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl N-Boc-4-methylpiperidine-4-carboxylate(189442-87-3)
• EPA Substance Registry System: Ethyl N-Boc-4-methylpiperidine-4-carboxylate(189442-87-3)

Safety Data

• Hazard Codes: T
• Statements: 25-37/38-41
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2810
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 189442-87-3(Hazardous Substances Data)

Usage

Uses

Reactant for synthesis of:Dipeptidyl peptidase-4 inhibitor ABT-279Building blocks for piperazine-based CCR5 antagonists

InChI:InChI=1/C14H25NO4/c1-6-18-11(16)14(5)7-9-15(10-8-14)12(17)19-13(2,3)4/h6-10H2,1-5H3

Upstream product

• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 74-88-4 methyl iodide 
• 1126-09-6 4-carbethoxypiperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 

Downstream Products

• 189321-63-9 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid 
• 343788-67-0 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 872850-48-1 tert-butyl 4-isocyanato-4-methylpiperidine-1-carboxylate 
• 741687-12-7 4-methyl-4-{3-methyl-2,5-dioxo-4-[1-(4-trifluoromethylphenyl)ethyl]piperazin-1-yl}piperidine-1-carboxylic acid tert-butyl ester 
• 828935-40-6 tert-butyl 4-(2-(((S)-1-methoxy-1-oxopropan-2-yl)((S)-1-(4-trifluoromethylphenyl)ethyl)amino)-2-oxoethylamino)-4-methyl-piperidine-1-carboxylate 
• 225240-71-1 ethyl 4-methylpiperidine-4-carboxylate monohydrochloride 
• 162648-32-0 4-methylpiperidine-4-carboxylic acid 
• 236406-21-6 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 1372544-52-9 1-{5-[7-Cyclohexyl-2-(3-ethyl-ureido)-benzothiazol-5-yl]-pyrimidin-2-yl}-4-methyl-piperidine-4-carboxylic acid 
• 1372548-42-9 ethyl 1-[5-[7-cyclohexyl-2-(ethylcarbamoylamino)-1,3-benzothiazol-5-yl]pyrimidin-2-yl]-4-methyl-piperidine-4-carboxylate 
• 236406-15-8 (4-methyl-piperidin-4-yl)-carbamic acid benzyl ester 
• 1067914-49-1 benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 
• 1067915-26-7 benzyl 1-(6-fluoro-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 
• 1067915-27-8 benzyl 1-(5-fluoro-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 

Relevant articles and documents

Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore

We have previously reported the development of indole-based CNS-active antivirals for the treatment of neurotropic alphavirus infection, but further optimization is impeded by a lack of knowledge of the molecular target and binding site. Herein we describe the design, synthesis and evaluation of a series of conformationally restricted analogues with the dual objectives of improving potency/selectivity and identifying the most bioactive conformation. Although this campaign was only modestly successful at improving potency, the sharply defined SAR of the rigid analogs enabled the definition of a three-dimensional pharmacophore, which we believe will be of value in further analog design and virtual screening for alternative antiviral leads.

CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF

Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.