2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

Base Information

Chemical Name:2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone
CAS No.:1190970-98-9
Molecular Formula:C₃₅H₄₆N₄O₆S
Molecular Weight:650.839
Hs Code.:

2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

Synonyms:2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

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Chemical Property of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

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Technology Process of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

There total 14 articles about 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1018827-17-2
2-((1-(4-methoxy-2, 6-dimethylphenyl-sulfonyl)piperidin-2-yl)methoxy) acetic acid

: 1190971-53-9
4-phenyl-3-(piperidin-1-ylmethyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine

: 1190970-98-9
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

Guidance literature:: 2-((1-(4-methoxy-2, 6-dimethylphenyl-sulfonyl)piperidin-2-yl)methoxy) acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

4-phenyl-3-(piperidin-1-ylmethyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 919119-04-3
N-acetyl-2-phenyl-4-oxopiperidine

: 1190970-98-9
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: hydrogenchloride; water / 0 - 130 °C

4.1: triethylamine / dichloromethane / 2 h / 20 °C

5.1: lithium hydroxide monohydrate; water / ethanol

6.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 12 h

7.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / 110 °C

7.2: 0 - 110 °C

7.3: Saturated solution

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

8.2: 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; dimethylsulfide borane complex; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1021373-55-6
[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-yl]-methanol

: 1190970-98-9
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-3-(piperidin-1-ylmethyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water; toluene / 0 - 20 °C

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

2.2: 0 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.2: 0 - 20 °C

With tetrabutyl-ammonium chloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;