Technology Process of 4-phenyl-3-(piperidin-1-ylmethyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine
There total 9 articles about 4-phenyl-3-(piperidin-1-ylmethyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 4-phenyl-3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 110 ℃;
for 6h;
With
hydrogenchloride; water;
In
tetrahydrofuran; methanol;
at 0 - 110 ℃;
With
sodium carbonate;
In
dichloromethane;
Saturated solution;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 12 h
2.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / 110 °C
2.2: 0 - 110 °C
2.3: Saturated solution
With
4-methyl-morpholine; dimethylsulfide borane complex; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 12 h
2.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / 110 °C
2.2: 0 - 110 °C
2.3: Saturated solution
With
4-methyl-morpholine; dimethylsulfide borane complex; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
![tert-butyl 4-phenyl-3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate](/Databaselist/images/loading.webp)
