Technology Process of C39H43F6N7O8
There total 4 articles about C39H43F6N7O8 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
{3-[N'-(3-tert-butoxycarbonylaminopropyl)-N''-(2,2,2-trifluoroacetyl)guanidino]propyl}carbamic acid tert-butyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
for 0.833333h;
C16H14F3NO5;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
With
potassium carbonate;
In
methanol;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bromine / acetic acid / 22 h / 20 °C
2.1: sodium hydroxide / water / 2 h / 100 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1.5 h / 80 °C
4.1: sodium hydroxide / methanol; water / 4 h
5.1: trifluoroacetic acid / dichloromethane / 0.83 h
5.2: 2 h / 20 °C
5.3: 1 h / 20 °C
With
sodium hydroxide; bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid;
In
methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 2 h / 100 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1.5 h / 80 °C
3.1: sodium hydroxide / methanol; water / 4 h
4.1: trifluoroacetic acid / dichloromethane / 0.83 h
4.2: 2 h / 20 °C
4.3: 1 h / 20 °C
With
sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
