694479-56-6

Upstream product

• 4652-27-1 4-methoxy-3-buten-2-one 
• 15386-86-4 ethyl 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate 
• 106109-76-6 methyl 3-oxo-3-(3-(trifluoromethyl)phenylamino)propanoate 
• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 98-16-8 3-trifluoromethylaniline 

Downstream Products

• 950857-20-2 C₅₀H₄₆F₆N₆O₆ 
• 950857-30-4 C₁₄H₉BrF₃NO₃ 
• 950856-73-2 C₃₃H₃₁F₆N₅O₄ 
• 950857-36-0 5-iodo-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxylic acid 
• 694475-15-5 6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1281969-57-0 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium benzenesulfonate 
• 1281969-55-8 5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-N-(3-(dimethylamino)propyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1281969-58-1 N-[3-(dimethylamino)propyl]-5-iodo-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1281969-54-7 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium bromide 
• 1281969-56-9 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate 
• 950857-05-3 C₃₃H₂₉Br₂F₆N₅O₄ 
• 950857-01-9 C₃₉H₄₃F₆N₇O₈ 
• 950857-56-4 C₂₀H₁₄F₃N₃O₅S 
• 950857-32-6 C₂₂H₂₂F₃NO₈ 

Relevant academic research and scientific papers

ELASTASE INHIBITORS

Described herein are compounds, compositions, and methods of their use for the treatment of a lung or intestinal disease.

Novel 2-Pyridone Compounds

The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R7, L, X and Y are as defined in the specification; together with processes and intermediates for their preparation,

NOVEL SALT 628

6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 4-methylbenzenesulfonate and a novel crystalline form thereof are disclosed together with processes for preparing such salt and form, pharmaceutical compositions comprising such a salt and form, and the methods of treatment using such a salt and form.

2-PYRIDONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL.

The invention provides compounds of formula (1) wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharma

2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE

The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptab

2-PYRIDONE DERIVATIVES AS NETROPHIL ELASTASE INHIBITORS AND THEIR USE

There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes

2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE

There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and p