3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol

Base Information

• Chemical Name: 3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol
• CAS No.: 878289-22-6
• Molecular Formula: C₂₇H₃₃NO₂
• Molecular Weight: 403.565
• Mol file: 878289-22-6.mol

Synonyms:3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol

Chemical Property of 3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol

There total 1 articles about 3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzaldehyde (100-52-7) + 17β-hydroxy-16β-aminomethylestrone 3-methyl ether (218281-26-6) → 3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol (878289-22-6)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1016/j.tetlet.2005.12.038 DOI:10.1016/j.steroids.2007.02.001

Reference yield: 95.0%

3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol (878289-22-6) → 3-methoxy-16β-(benzylaminomethyl)estra-1,3,5(10)-trien-17β-ol (878289-23-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2005.12.038

Reference yield:

3-methoxy-16β-(benzylideneiminomethyl)estra-1,3,5(10)-trien-17β-ol (878289-22-6) → (4bS,6aS,6bS,8S,10aR,11aS,11bR)-9-Benzyl-2-methoxy-6a-methyl-8-phenyl-5,6,6a,6b,9,10,10a,11,11a,11b,12,13-dodecahydro-4bH-7-oxa-9-aza-8-phospha-indeno[2,1-a]phenanthrene 8-oxide

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h / 20 °C

2: Et₃N / CH₂Cl₂ / 6 h / Heating

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tetlet.2005.12.038

upstream raw materials:

benzaldehyde

17β-hydroxy-16β-aminomethylestrone 3-methyl ether

Downstream raw materials:

3-methoxy-16β-(benzylaminomethyl)estra-1,3,5(10)-trien-17β-ol