2-(6-Bromo-1H-indol-3-YL)ethanamine hydrochloride

Base Information

• Chemical Name: 2-(6-Bromo-1H-indol-3-YL)ethanamine hydrochloride
• CAS No.: 108061-77-4
• Molecular Formula: C10H11 Br N2 . Cl H
• Molecular Weight: 0
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40695232
• Mol file: 108061-77-4.mol

Synonyms:108061-77-4;2-(6-BROMO-1H-INDOL-3-YL)ETHANAMINE HYDROCHLORIDE;2-(6-BROMO-1H-INDOL-3-YL)ETHANAMINE HCL;6-Bromo-1H-indole-3-ethanamine Hydrochloride;MFCD11109987;2-(6-bromo-1H-indol-3-yl)ethanamine;hydrochloride;1H-Indole-3-ethanamine, 6-bromo-, monohydrochloride;SCHEMBL2706928;AMY7766;DTXSID40695232;BCP29990;AKOS016001542;AS-30893;SY112831;6-Bromo-1H-indole-3-ethanamine monohydrochloride;EN300-7410302;A853534;2-(6-bromo-1H-indol-3-yl)ethan-1-amine hydrochloride;Z3235022918;2-(6-Bromo-1H-indol-3-yl)ethan-1-amine--hydrogen chloride (1/1);2-(6-bromo-1H-indol-3-yl)ethanamine hydrochloride;6-Bromo-3-(2-aminoethyl)-1H-indole hydrochloride

Chemical Property of 2-(6-Bromo-1H-indol-3-YL)ethanamine hydrochloride

Chemical Property:

• PSA: 41.81000
• LogP: 3.93390
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 273.98724
• Heavy Atom Count: 14
• Complexity: 174

Purity/Quality:

98%min ^*data from raw suppliers

2-(6-Bromo-1H-indol-3-yl)ethanamine hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1Br)NC=C2CCN.Cl

Technology Process of 2-(6-Bromo-1H-indol-3-YL)ethanamine hydrochloride

There total 2 articles about 2-(6-Bromo-1H-indol-3-YL)ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl (2-(6-bromo-1H-indol-3-yl)ethyl)carbamate (209168-88-7) → 6-bromotryptamine hydrochloride (108061-77-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00306-8

Reference yield:

indole-3-glyoxylamide (5548-10-7) → 6-bromotryptamine hydrochloride (108061-77-4)

Guidance literature:

Multi-step reaction with 2 steps

2: 93 percent / HCl / ethanol; H₂O / 2 h / Ambient temperature

With hydrogenchloride; In ethanol; water;

DOI:10.1016/S0040-4020(98)00306-8

Reference yield: 73.0%

4-methylsulphonyloxyphenylacetaldehyde (74447-37-3) + 6-bromotryptamine hydrochloride (108061-77-4) → 4-((7-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate (1435263-69-6)

Guidance literature:

In isopropyl alcohol; at 87 ℃; for 15h;

DOI:10.1039/c3ob40661j

upstream raw materials:

tert-butyl (2-(6-bromo-1H-indol-3-yl)ethyl)carbamate

indole-3-glyoxylamide

Downstream raw materials:

7-bromo-9H-pyrido[3,4-b]indole

7-bromo-1,2,3,4-tetrahydro-β-carboline

4-((7-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate

Refernces