4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile

Base Information

Chemical Name:4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile
CAS No.:1430745-38-2
Molecular Formula:C₂₃H₂₆ClN₅O₂
Molecular Weight:439.945
Hs Code.:

Synonyms:4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile

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Chemical Property of 4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile

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Technology Process of 4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile

There total 4 articles about 4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.3%

: 22536-67-0
2,5-dichloropyrimidine

: 4-((1R,4r)-4-((1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile dihydrochloride

: 1430745-38-2
4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile

Guidance literature:: With triethylamine; In isopropyl alcohol; at 120 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1430747-29-7
(1R,3s,5S)-tert-butyl 3-(4-hydroxycyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1430745-38-2
4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

3: triethylamine / isopropyl alcohol / 3 h / 120 °C / Microwave irradiation

With hydrogenchloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol;

Reference yield:

: 89284-61-7
4-chloro-nicotinonitrile

: 1430745-38-2
4-((1R,4r)-4-((1R,3s,5S)-8-(5-chloropyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yloxy)cyclohexyloxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

3: triethylamine / isopropyl alcohol / 3 h / 120 °C / Microwave irradiation

With hydrogenchloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol;