2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone

Base Information

• Chemical Name: 2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone
• CAS No.: 76999-37-6
• Molecular Formula: C₁₄H₂₄OSi
• Molecular Weight: 236.429
• Mol file: 76999-37-6.mol

Synonyms:2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone

Chemical Property of 2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone

There total 1 articles about 2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyldimedone isobutyl ether (76999-35-4) + tributyl[(E)-2-trimethylsilylethenyl]stannane (58207-97-9) → 2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone (76999-37-6)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, -78 deg C, 50 min; -33 deg C, 50min, 2.) from -78 deg C to room temp., 4.5 h;

DOI:10.1021/jo00324a041

Reference yield: 99.0%

2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone (76999-37-6) → 2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enol (77011-22-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 4h;

DOI:10.1021/jo00324a041

Reference yield:

2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enone (76999-37-6) → [2,5,5-Trimethyl-1-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enyl]-acetaldehyde (76999-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / lithium aluminium hydride / diethyl ether / 4 h / 0 °C

2: 1) Hg(OAc)2 / 1) reflux, overnight, 2a) 187 deg C, 5.75 h, b) 200 deg C, 30 min

With lithium aluminium tetrahydride; mercury(II) diacetate; In diethyl ether;

DOI:10.1021/jo00324a041

upstream raw materials:

2-methyldimedone isobutyl ether

tributyl[(E)-2-trimethylsilylethenyl]stannane

Downstream raw materials:

2,5,5-Trimethyl-3-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enol

[2,5,5-Trimethyl-1-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enyl]-acetaldehyde

[2,5,5-Trimethyl-1-((E)-2-trimethylsilanyl-vinyl)-cyclohex-2-enyl]-acetic acid