2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine

Base Information

Chemical Name:2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine
CAS No.:1262118-39-7
Molecular Formula:C₁₉H₁₃F₆N₃OS
Molecular Weight:445.388
Hs Code.:

Synonyms:2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine

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Chemical Property of 2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine

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Technology Process of 2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine

There total 2 articles about 2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 130783-02-7
3,5-bis(trifluoromethyl)thiophenol

: 350819-24-8
2-amino-3-bromo-5-(4'-methoxyphenyl)-1,4-pyrazine

: 1262118-39-7
2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine

Guidance literature:: 3,5-bis(trifluoromethyl)thiophenol; With sodium hydride; In N,N-dimethyl-formamide; for 0.25h;

2-amino-3-bromo-5-(4'-methoxyphenyl)-1,4-pyrazine; In N,N-dimethyl-formamide; at 110 ℃; for 4.5h;

Reference yield:

: 119738-50-0
2-amino-5-(4'-methoxyphenyl)-1,4-pyrazine

: 1262118-39-7
2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine; pyridine / chloroform / 6 h / -10 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h

2.2: 4.5 h / 110 °C

With pyridine; bromine; sodium hydride; In chloroform; N,N-dimethyl-formamide;