119738-50-0

Basic information

• Product Name: 5-(4-methoxyphenyl)pyrazin-2-amine
• Synonyms: 5-(4-methoxyphenyl)pyrazin-2-amine
• CAS NO: 119738-50-0
• Molecular Formula: C₁₁H₁₁N₃O
• Molecular Weight: 201.22454
• Mol File: 119738-50-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 374.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.201±0.06 g/cm3(Predicted)
• PKA: 3.02±0.10(Predicted)
• CAS DataBase Reference: 5-(4-methoxyphenyl)pyrazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)pyrazin-2-amine(119738-50-0)
• EPA Substance Registry System: 5-(4-methoxyphenyl)pyrazin-2-amine(119738-50-0)

Safety Data

• Hazardous Substances Data: 119738-50-0(Hazardous Substances Data)

Usage

Uses

5-(4-Methoxyphenyl)pyrazinamine, is a building block used in synthesis of coelenterazine and coelenteramine derivatives as inhibitors of lipid peroxidation.

Upstream product

• 5049-61-6 2-Aminopyrazine 
• 104-94-9 4-methoxy-aniline 
• 1087036-79-0 N-[(3'-bromo-5'-(4''-methoxyphenyl))pyrazin-2'-yl]pyridinium aminide 
• 59489-71-3 5-amino-2-bromopyrazine 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 128322-44-1 6-(4-methoxyphenyl)-2-methylimidazo<1,2-a>pyrazin-3(7H)-one hydrochloride 
• 1262118-36-4 2-amino-5-(4-methoxyphenyl)-3-phenylthiopyrazine 
• 1262118-38-6 2-amino-5-(4-methoxyphenyl)-3-(4-chlorophenyl)thiopyrazine 
• 1262118-39-7 2-amino-5-(4-methoxyphenyl)-3-(3,5-bis-trifluoromethylphenyl)thiopyrazine 
• 1262118-40-0 2-amino-5-(4-methoxyphenyl)-3-(4-methylphenyl)thiopyrazine 
• 1262118-41-1 2-amino-5-(4-methoxyphenyl)-3-(4-methoxyphenyl)thiopyrazine 
• 1262118-42-2 2-amino-5-(4-methoxyphenyl)-3-methylthiopyrazine 
• 1449112-33-7 4-(5-amino-6-bromopyrazin-2-yl)phenol 
• 1363438-88-3 2-Ethynyl-5-(4-methoxyphenyl)pyrazine 
• 1363438-56-5 2-(4-methoxyphenyl)-5-((trimethylsilyl)ethynyl)pyrazine 
• 1363438-32-7 2-iodo-5-(4-methoxyphenyl)pyrazine 
• 118877-07-9 MCLA 

Relevant articles and documents

Iridium-Catalyzed Asymmetric Hydrogenation of Tosylamido-Substituted Pyrazines for Constructing Chiral Tetrahydropyrazines with an Amidine Skelton

Dinuclear triply chloro-bridged iridium(III) complexes bearing chiral diphosphine ligands catalyze the asymmetric hydrogenation of tosylamido-substituted pyrazines to give the corresponding chiral tetrahydropyrazines with an amidine skeleton in high yield and with high enantioselectivity. Addition of N,N-dimethylanilinium bromide enhanced the catalytic activity of the iridium complexes and also increased the enantioselectivity of the products by trapping the hydrogenated amine products with HBr from N,N-dimethylanilinium bromide. The amidine skeleton of the products could be transformed to give chiral piperazinones and piperazines without loss of enantioselectivity. (Figure presented.).

Chemical synthesis of coelenterazine and its analogs: New route by four segment-couplings

A novel and improved synthetic route includes four segment-couplings toward coelenterazine and its analogs as luminescent molecules. Regio- and chemo-selective cross coupling reactions using palladium catalysts with 5-iodo-3-bromo-2-aminopyrazine have enabled providing various aminopyrazine derivatives having different substituents. The improved synthesis of coelenterazine and its analogs employed advanced condensation with the aminopyrazines using various keto-acetal segments, which resulted in much higher yields to give the final imidazopyrazinone heterocycles than the previous method using keto-aldehydes.

IMIDAZO[1,2-α]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE

The present invention relates to compound of formula I : and their use as chemiluminescent and/or bioluminescent reagents.