N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester

Base Information

Chemical Name:N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester
CAS No.:254441-35-5
Molecular Formula:C₃₁H₂₉ClNO₃P
Molecular Weight:530.003
Hs Code.:

Synonyms:N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester

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Chemical Property of N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester

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Technology Process of N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester

There total 4 articles about N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: N-(4-chlorophenyl)acetyl-N-methylglycine

: 254441-31-1
2-(di-o-tolylphosphino)phenol

: 254441-35-5
N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/S0022-328X(99)00311-3

Reference yield:

: 824-91-9
O-methoxymethylphenol

: 254441-35-5
N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester

Guidance literature:: Multi-step reaction with 3 steps

1: t-BuLi / diethyl ether; hexane / 15 h / 20 °C

2: HCl / methanol / 24 h

3: 51 percent / DCC; DMAP / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With hydrogenchloride; dmap; tert.-butyl lithium; dicyclohexyl-carbodiimide; In methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Esterification;
DOI:10.1016/S0022-328X(99)00311-3

Reference yield:

: 36042-94-1
bis(o-tolyl)chlorophosphine

: 254441-35-5
N-(4-chlorophenyl)acetyl-N-methylglycine, 2-(di-o-tolylphosphino)phenol ester

Guidance literature:: Multi-step reaction with 3 steps

1: t-BuLi / diethyl ether; hexane / 15 h / 20 °C

2: HCl / methanol / 24 h

3: 51 percent / DCC; DMAP / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With hydrogenchloride; dmap; tert.-butyl lithium; dicyclohexyl-carbodiimide; In methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Esterification;
DOI:10.1016/S0022-328X(99)00311-3