1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester
CAS No.:222026-56-4
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:

1-benzyl-4-methyl-3-(4-nitro-phenyl)-1<i>H</i>-pyrrole-2-carboxylic acid <i>tert</i>-butyl ester

Synonyms:1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

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Chemical Property of 1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

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Technology Process of 1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

There total 7 articles about 1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 100-39-0
benzyl bromide

: 222026-08-6
4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 222026-56-4
1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

Guidance literature:: With polystyrene supported 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine; In dichloromethane;
DOI:10.1039/a809345h

Reference yield:

: 619-73-8
4-nitrobenzyl chloride

: 222026-56-4
1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Amberlyst A-27 supported permanganate / CH₂Cl₂

2: Amberlite IRA-420 (OH-form)

3: CH₂Cl₂

4: NEt₃ / CH₂Cl₂

5: polystyrene supported 1,5,7-triazabicyclo<4.4.0>dec-5-ene / tetrahydrofuran; propan-2-ol

6: 89 percent / polystyrene supported 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine / CH₂Cl₂

With 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL; Amberlite IRA-420 (OH-form); Amberlyst A-27 supported permanganate; polystyrene supported 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1039/a809345h

Reference yield:

: 52287-53-3
1-nitro-4-[(1E)-2-nitro-1-propenyl]benzene

: 222026-56-4
1-benzyl-4-methyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: polystyrene supported 1,5,7-triazabicyclo<4.4.0>dec-5-ene / tetrahydrofuran; propan-2-ol

2: 89 percent / polystyrene supported 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine / CH₂Cl₂

With 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL; polystyrene supported 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1039/a809345h