methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate

Base Information

Chemical Name:methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate
CAS No.:959999-80-5
Molecular Formula:C₂₂H₁₆ClF₃N₂O₅S
Molecular Weight:512.894
Hs Code.:

Synonyms:methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate

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Chemical Property of methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate

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Technology Process of methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate

There total 12 articles about methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95668-21-6
1-bromo-2-nitro-4-(trifluoromethoxy)benzene

: 959999-80-5
methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 60 °C

2: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 36 h / 38002.6 Torr

3: pyridinium p-toluenesulfonate / 24 h

4: trifluoroacetic acid / chloroform / 2 h / 60 °C

5: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 1 h

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

With di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5 % platinum on sulfided carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; ethyl acetate; 1: Suzuki Coupling / 5: Mitsunobu reaction;

Reference yield:

: 2267-23-4
2-nitro-4-trifluoromethoxyaniline

: 959999-80-5
methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 20 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 60 °C

3: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 36 h / 38002.6 Torr

4: pyridinium p-toluenesulfonate / 24 h

5: trifluoroacetic acid / chloroform / 2 h / 60 °C

6: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 1 h

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

With tert.-butylnitrite; di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; copper(ll) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5 % platinum on sulfided carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; ethyl acetate; acetonitrile; 2: Suzuki Coupling / 6: Mitsunobu reaction;

Reference yield:

: 959999-81-6
methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-({2-nitro-4-[(trifluoromethyl)oxy]phenyl}amino)-2-thiophenecarboxylate

: 959999-80-5
methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 36 h / 38002.6 Torr

2: pyridinium p-toluenesulfonate / 24 h

3: trifluoroacetic acid / chloroform / 2 h / 60 °C

4: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 1 h

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

With di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; triphenylphosphine; trifluoroacetic acid; 5 % platinum on sulfided carbon; In tetrahydrofuran; dichloromethane; chloroform; ethyl acetate; 4: Mitsunobu reaction;