1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone

Base Information

Chemical Name:1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone
CAS No.:929280-82-0
Molecular Formula:C₁₄H₂₁ClO₂Si
Molecular Weight:284.858
Hs Code.:

Synonyms:1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone

Chemical Property:

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Technology Process of 1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone

There total 1 articles about 1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 69240-96-6
1-(2-chloro-3-hydroxyphenyl)ethanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 929280-82-0
1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 929280-82-0
1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone

: 929280-80-8
(1S)-1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-phenyl)ethanol

Guidance literature:: 1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone; With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 18h;

With methanol; In tetrahydrofuran; toluene; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 929280-82-0
1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethanone

: C₂₇H₂₇Cl₂N₃O₄S

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 20 h

2: PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 2 h

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 2 h

With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; triphenylphosphine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; toluene; 2: Mitsunobu reaction;