(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

Base Information

Chemical Name:(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol
CAS No.:133299-31-7
Molecular Formula:C₂₉H₃₅N₅O₆
Molecular Weight:549.627
Hs Code.:

Synonyms:(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

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Chemical Property of (1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

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Technology Process of (1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

There total 3 articles about (1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117641-39-1
(2R,3S)-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexan-3-ol

: 133299-31-7
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH, 2) tetrabutylammonium iodide / 1) THF, r.t., 1 h, 2) DMF, reflux, 1.5 h

2: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

With tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride;
DOI:10.1039/P19910002479

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 133299-31-7
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH, 2) tetrabutylammonium iodide / 1) THF, r.t., 1 h, 2) DMF, reflux, 1.5 h

2: 1) lithium hydride / 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h

With tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride;
DOI:10.1039/P19910002479

Reference yield:

: 105797-60-2
2-amino-6-(2-methoxyethoxy)purine

: 133299-26-0
(1S,2R,3S,5R)-2-benzyloxymethyl-3-(4-methoxybenzyloxy)-6-oxabicyclo<3.1.0>hexane

: 133299-31-7
(1S,2R,3S,5S)-5-<2-amino-6-(2-methoxyethoxy)-9H-purin-9-yl>-2-benzyloxymethyl-3-(4-methoxybenzyloxy)cyclopentanol

Guidance literature:: With lithium hydride; Yield given. Multistep reaction; 1) DMF, 120 deg C, 1 h, 2) DMF, 145 deg C, 3.5 h;
DOI:10.1039/P19910002479