133299-26-0Relevant academic research and scientific papers
The enantiomers of the 1′,6′-isomer of neplanocin A: Synthesis and antiviral properties
Ye, Wei,Schneller, Stewart W.
, p. 5315 - 5319 (2014)
Both enantiomers of 1′,6′-isoneplanocin have been prepared from a common substituted cyclopentane epoxide in 7 steps. Both compounds were subjected to DNA and RNA viral assessments with moderate to high activity found for both towards human cytomegaloviru
ENANTIOMERS OF THE 1',6'-ISOMER OF NEPLANOCIN A
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Page/Page column 31-32, (2016/04/20)
Enantiomers of 1',6'-isoneplanocin, including derivatives of the enantiomers of 1',6'-isoneplanocin, are disclosed along with novel synthetic methods. In particular, a substituted cyclopentane epoxide is synthesized into the enantiomers of 1',6'-isoneplan
Novel 3′-deoxy analogs of the anti-HBV agent entecavir: Synthesis of enantiomers from a single chiral epoxide
Ruediger, Edward,Martel, Alain,Meanwell, Nicholas,Solomon, Carola,Turmel, Brigitte
, p. 739 - 742 (2007/10/03)
A synthesis of novel 3′-deoxy analogs of the anti-HBV agent entecavir (BMS-200475) was devised using regioselective ring opening of suitable cyclopentene epoxides as the key step. This versatile approach afforded access to an enantiomeric pair of carbocyclic nucleosides from a single chiral intermediate.
Total Synthesis of (-)-Carbovir
Jones, Martin F.,Myers, Peter L.,Robertson, Colin A.,Storer, Richard,Williamson, Christopher
, p. 2479 - 2484 (2007/10/02)
Optically pure (-)-carbovir has been prepared by two different routes involving stereospecific opening of chiral cyclopentene epoxides by substituted purines.Introduction of the 2',3' unsaturation was accomplished by mesylate elimination, either after int
