(S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid

Base Information

Chemical Name:(S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid
CAS No.:1428526-40-2
Molecular Formula:C₁₈H₁₇N₄O₅P
Molecular Weight:400.331
Hs Code.:

Synonyms:(S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid

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Chemical Property of (S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid

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Technology Process of (S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid

There total 5 articles about (S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428526-39-9
diethyl (S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

: 1428526-40-2
(S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 1428526-40-2
(S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium methylate / methanol / Reflux

3.1: thionyl chloride / 3 h / 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With thionyl chloride; trimethylsilyl bromide; sodium methylate; triethylamine; In methanol; dichloromethane;

Reference yield:

: 51285-26-8,61097-49-2
pyridine-2-carboxamidine hydrochloride

: 1428526-40-2
(S)-4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / methanol / Reflux

2: thionyl chloride / 3 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

With thionyl chloride; trimethylsilyl bromide; sodium methylate; triethylamine; In methanol; dichloromethane;