4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylic acid

Base Information

• Chemical Name: 4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylic acid
• CAS No.: 56406-45-2
• Molecular Formula: C10H7N3O3
• Molecular Weight: 217.184
• Hs Code.: 2933990090
• Mol file: 56406-45-2.mol

Synonyms:4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylic acid

Chemical Property of 4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylic acid

Chemical Property:

• Melting Point: 330°(dec)
• PKA: 2.70±0.20(Predicted)
• PSA: 96.20000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 0.94240
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylic acid

There total 6 articles about 4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

pyridine-2-carboxamidine hydrochloride (51285-26-8,61097-49-2) + diethyl 2-ethoxymethylenemalonate (87-13-8) → 4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid (56406-45-2)

Guidance literature:

pyridine-2-carboxamidine hydrochloride; diethyl 2-ethoxymethylenemalonate; With sodium methylate; In methanol; Reflux;

With water; potassium hydroxide; In methanol; for 2h; Reflux;

With hydrogenchloride; In methanol; water; at 20 ℃; for 2h;

Reference yield:

→ 4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid (56406-45-2) + 2-(3'-Pyridyl)-4-hydroxy-5-carboxy-pyrimidin (56406-46-3)

Guidance literature:

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → 4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid (56406-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium methylate / methanol / Reflux

2.2: 2 h / Reflux

2.3: 2 h / 20 °C

With sodium methylate; In methanol;

upstream raw materials:

2-Cyanopyridine

pyridine-2-carboxamidine hydrochloride

diethyl 2-ethoxymethylenemalonate

4-oxo-2-pyridin-2-yl-3,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

Downstream raw materials:

benzyl N-[4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl]carbamate

N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

4-hydroxy-N-(2-phenylpropan-2-yl)-2-(pyridin-2-yl)-pyrimidine-5-carboxamide

3-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphonic acid

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINES". . . Retrieved 2013/04/10.
• 2、 -. "SUBSTITUTED PYRIMIDINES". . . Retrieved 2011/11/06.