(R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester

Base Information

• Chemical Name: (R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester
• CAS No.: 200435-35-4
• Molecular Formula: C₂₈H₃₁NO₃S₂
• Molecular Weight: 493.691
• Mol file: 200435-35-4.mol

Synonyms:(R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester

Chemical Property of (R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester

There total 3 articles about (R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

D-penicillamine methyl ester + 3-(tritylthio)propanoyl chloride (80612-83-5) → (R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester (200435-35-4)

Guidance literature:

With triethylamine; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(97)10087-4

Reference yield:

3-(tritylthio) propanoic acid (27144-18-9) → (R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester (200435-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / oxalyl chloride, N,N-dimethylformamide

2: 21 percent / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/S0040-4020(97)10087-4

Reference yield:

trityl chloride (76-83-5) → (R)-3-Mercapto-3-methyl-2-(3-tritylsulfanyl-propionylamino)-butyric acid methyl ester (200435-35-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent

2: 70 percent / oxalyl chloride, N,N-dimethylformamide

3: 21 percent / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/S0040-4020(97)10087-4

upstream raw materials:

3-(tritylthio)propanoyl chloride

3-(tritylthio) propanoic acid

trityl chloride