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27144-18-9

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27144-18-9 Usage

Chemical Properties

White to off-white powder

Uses

Preparation and structural modification of 3-Tritylsulfanylpropionic Acid possesses antileukemic activity against leukemia.

Check Digit Verification of cas no

The CAS Registry Mumber 27144-18-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,1,4 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 27144-18:
(7*2)+(6*7)+(5*1)+(4*4)+(3*4)+(2*1)+(1*8)=99
99 % 10 = 9
So 27144-18-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H20O2S/c23-21(24)16-17-25-22(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15H,16-17H2,(H,23,24)

27144-18-9 Well-known Company Product Price

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  • Alfa Aesar

  • (H60093)  3-(Tritylthio)propionic acid, 97%   

  • 27144-18-9

  • 1g

  • 766.0CNY

  • Detail

27144-18-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-tritylsulfanylpropanoic acid

1.2 Other means of identification

Product number -
Other names S-Trityl-3-Mercaptopropionic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:27144-18-9 SDS

27144-18-9Relevant articles and documents

Stabilization of polymerized vesicular systems: An application of the dynamic molecular shape concept

Wathier, Michel,Polidori, Ange,Ruiz, Karine,Fabiano, Anne-Sylvie,Pucci, Bernard

, p. 17 - 37 (2002)

A series of glycolipid surfactants derived from Tris(hydroxymethyl)acrylamidomethane (THAM) and bearing hydrocarbon or perfluorocarbon tails and an acryloyl group attached to their polar head was prepared to explore the aqueous behavior of the supramolecular systems they form. The dispersion of surfactants was achieved in water under ultrasonication conditions. Hydrocarbon compounds give heterogeneous vesicular assemblies. In the case of perfluorocarbon derivatives homogeneous vesicles were obtained. However after 1-day storage, all these systems fuse. To stabilize these vesicles, polymerization by ultra violet (UV) irradiation was carried out. During this reaction, a precipitation in water was observed for the hydrocarbon surfactants, whereas fluorocarbon structures provide stable vesicles without any alteration of their size. According to these results, the polymerization process was achieved, in the case of hydrocarbon glycolipid, in the presence of different cosurfactants bearing a single hydrocarbon tail or a polyhydroxylated head and a cholesterol terminus. In such conditions, homogeneous stable vesicles were prepared. Moreover, the THAM derived telomers bearing a cholesterol terminus were able to stabilize and reduce the size of vesicles formed with synthetic glycolipid surfactants. The drug encapsulation ability of these systems was investigated by measurement of the release kinetics of a fluorescent dye, carboxyfluorescein (CF), before and after polymerization.

Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery

Tanaka, Ko,Kanazawa, Takanori,Shibata, Yasunori,Suda, Yumiko,Fukuda, Tsunehiko,Takashima, Yuuki,Okada, Hiroaki

, p. 229 - 238 (2010)

To develop a safe and efficient systemic non-viral gene vector, methoxy poly(ethylene glycol) (MPEG)/poly(e{open}-caprolactone) (PCL) diblock copolymers conjugated with a Tat analog through the ester or disulfide linkage were synthesized and their suitability as a systemic non-viral gene carrier evaluated. The physicochemical properties of the MPEG-PCL diblock copolymers were determined by GPC, 1H NMR and FT-IR spectroscopy. The particle sizes and in vitro (COS7 and S-180 cells) transfection efficiencies and cytotoxicity were evaluated. Furthermore, the luciferase activity was then determined in various tissues after intravenous injection of MPEG-PCL-SS-Tat/pCMV-Luc complex into mice bearing S-180 cells. The particle sizes of the MPEG-PCL-Tat copolymers with or without pDNA were about 40 and 60nm, respectively. The luciferase activity in COS7 cells transfected with pCMV-Luc with MPEG-PCL-ester-Tat or MPEG-PCL-SS-Tat was higher than that with pDNA only. MPEG-PCL-SS-Tat greatly increased the transfection efficiency compared to MPEG-PCL-ester-Tat in COS7 and S-180 cells. In an in vitro cytotoxicity test MPEG-PCL-SS-Tat did not induce any remarkable cytotoxicity. In an in vivo experiment, the synthesized MPEG-PCL-SS-Tat copolymers promoted the delivery and expression of pDNA into tumor tissue in tumor-bearing mice. In conclusion, this vector might be applicable as a tumor-targeting non-viral systemic gene carrier in the clinical setting.

Conformational control in a photoswitchable coiled coil

Torner, Justin M.,Arora, Paramjit S.

, p. 1442 - 1445 (2021)

The coiled coil is a common protein tertiary structure intimately involved in mediating protein recognition and function. Due to their structural simplicity, coiled coils have served as attractive scaffolds for the development of functional biomaterials. Herein we describe the design of conformationally-defined coiled coil photoswitches as potential environmentally-sensitive biomaterials.

A hetero-bifunctional spacer for the smart engineering of carbon-based nanostructures

Tuci, Giulia,Luconi, Lapo,Rossin, Andrea,Baldini, Francesco,Cicchi, Stefano,Tombelli, Sara,Trono, Cosimo,Giannetti, Ambra,Manet, Ilse,Fedeli, Stefano,Brandi, Alberto,Giambastiani, Giuliano

, p. 704 - 714 (2015)

Efforts have been made in recent years to develop novel functionalisation protocols aimed at imparting multimodality and improved properties to complex carbon-based nanostructures. The incorporation of cleavable bonds to the nanomaterial surface for the controlled release (or exchange) of specific molecules under appropriate chemical and biological settings is relatively unexplored. The design and synthesis of a hetero-bifunctional linker joining a "cleavable" disulfide moiety for the covalent anchoring of a wide range of thiol end-capped (bio)molecules and a "clickable" terminal acetylene group is described. The strategy is based on the well-established copper-mediated acetylene-azide coupling reaction between the acetylene linker and single-walled carbon nanotubes decorated with phenylazido pendant arms. As a result, easily "post-derivatisable" and traceable nanostructured platforms containing a linking group potentially available for a wide range of biological probes are prepared and completely characterised.

Thiol- And Disulfide-Containing Vancomycin Derivatives against Bacterial Resistance and Biofilm Formation

Gademann, Karl,Shchelik, Inga S.

supporting information, p. 1898 - 1904 (2021/11/16)

Antibiotic-resistant and biofilm-associated infections constitute a rapidly growing issue. Use of the last-resort antibiotic vancomycin is under threat due to the increasing appearance of vancomycin-resistant bacteria as well as the formation of biofilms. Herein, we report a series of novel vancomycin derivatives carrying thiol- and disulfide-containing moieties. The new compounds exhibited enhanced antibacterial activity against a broad range of bacterial strains, including vancomycin-resistant microbes and Gram-negative bacteria. Moreover, all obtained derivatives demonstrated improved antibiofilm formation activity against VanB-resistant Enterococcus compared to vancomycin. This work establishes a promising strategy for combating drug-resistant bacterial infections or disrupting biofilm formation and advances the knowledge on the structural optimization of antibiotics with sulfur-containing modifications.

Multi-hydrogen sulfide fluorescent probe as well as preparation method and application thereof (by machine translation)

-

Paragraph 0041-0043, (2020/11/05)

The invention belongs to the technical field of fluorescent probes, and particularly relates to a multi-hydrogen sulfide fluorescent probe as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) condensing 2 - mercaptoacetic acid or 2 - mercaptopropionic acid with triphenylphosphine to obtain an intermediate; 2) reacting the intermediate obtained in step 1) with a fluorescein to obtain the multi-hydrogen sulfide fluorescent probe. The multi-hydrogen sulfide fluorescent probe is used for detecting multiple hydrogen sulfide, has high selectivity, high sensitivity and detection H. 2 Sn The concentration is convenient and fast. (by machine translation)

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