1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one

Base Information

Chemical Name:1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one
CAS No.:1027467-20-4
Molecular Formula:C₂₂H₁₉NO₅
Molecular Weight:377.397
Hs Code.:

Synonyms:1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one

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Chemical Property of 1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one

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Technology Process of 1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one

There total 6 articles about 1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1027467-20-4
1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2.1: 91 percent / NaO-tBu; cyclohexanone / toluene / 0.5 h / Heating

3.1: NaH / diethyl ether; tetrahydrofuran / 0.75 h / 20 °C

3.2: diethyl ether; tetrahydrofuran / 3 h / 55 °C

4.1: ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

5.1: 70percent HNO₃; AcOH / 0.5 h / 20 °C

With ammonium formate; cyclohexanone; sodium hydride; acetic acid; sodium t-butanolate; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; toluene; 2.1: Oppenauer oxidation;
DOI:10.1021/jm0109964

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 1027467-20-4
1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / K₂CO₃ / acetone / 2 h / Heating

2.1: 93 percent / diethyl ether; tetrahydrofuran / 1 h / 20 °C

3.1: 91 percent / NaO-tBu; cyclohexanone / toluene / 0.5 h / Heating

4.1: NaH / diethyl ether; tetrahydrofuran / 0.75 h / 20 °C

4.2: diethyl ether; tetrahydrofuran / 3 h / 55 °C

5.1: ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

6.1: 70percent HNO₃; AcOH / 0.5 h / 20 °C

With ammonium formate; cyclohexanone; sodium hydride; potassium carbonate; acetic acid; sodium t-butanolate; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; acetone; toluene; 3.1: Oppenauer oxidation;
DOI:10.1021/jm0109964

Reference yield:

: 274925-96-1
1-(4-benzyloxy-3-methoxyphenyl)-2-phenyl-ethanone

: 1027467-20-4
1-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2,3-diphenyl-propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / diethyl ether; tetrahydrofuran / 0.75 h / 20 °C

1.2: diethyl ether; tetrahydrofuran / 3 h / 55 °C

2.1: ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

3.1: 70percent HNO₃; AcOH / 0.5 h / 20 °C

With ammonium formate; sodium hydride; acetic acid; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jm0109964