3-fluoro-4-nitrobenzyl phosphonate

Base Information

• Chemical Name: 3-fluoro-4-nitrobenzyl phosphonate
• CAS No.: 1132941-95-7
• Molecular Formula: C₁₁H₁₅FNO₅P
• Molecular Weight: 291.216
• Mol file: 1132941-95-7.mol

Synonyms:3-fluoro-4-nitrobenzyl phosphonate

Chemical Property of 3-fluoro-4-nitrobenzyl phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-4-nitrobenzyl phosphonate

There total 3 articles about 3-fluoro-4-nitrobenzyl phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-(bromomethyl)-2-fluoro-1-nitrobenzene (131858-37-2) + triethyl phosphite (122-52-1) → 3-fluoro-4-nitrobenzyl phosphonate (1132941-95-7)

Guidance literature:

at 120 ℃; for 1h;

DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

(3-fluoro-4-nitrophenyl)methanol (503315-74-0) → 3-fluoro-4-nitrobenzyl phosphonate (1132941-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; triphenylphosphine / tetrahydrofuran; dichloromethane / 3 h / 20 °C

2: 1 h / 120 °C

With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

3-fluoro-4-nitrobenzoic acid (403-21-4) → 3-fluoro-4-nitrobenzyl phosphonate (1132941-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfide borane / tetrahydrofuran / 21 h / 0 - 65 °C

2: N-Bromosuccinimide; triphenylphosphine / tetrahydrofuran; dichloromethane / 3 h / 20 °C

3: 1 h / 120 °C

With N-Bromosuccinimide; dimethyl sulfide borane; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.jmedchem.7b01630

upstream raw materials:

4-(bromomethyl)-2-fluoro-1-nitrobenzene

triethyl phosphite

(3-fluoro-4-nitrophenyl)methanol

3-fluoro-4-nitrobenzoic acid

Downstream raw materials:

(E)-N-(4-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)-2-fluorophenyl)methanesulfonamidede

1-(2-amino-2-methylpropyl)-3-(2-fluoro-4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methyl)phenyl)urea

2-(4-((4-(4-aminobenzylidene)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

tert-butyl 4-(4-aminobenzylidene)piperidine-1-carboxylate

Refernces

• 1、 -. "(1,1, 1,3, 3, 3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS". Page/Page column 37. . Retrieved 2011/05/11.