cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one

Base Information

• Chemical Name: cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one
• CAS No.: 124286-84-6
• Molecular Formula: C₁₇H₂₃NO
• Molecular Weight: 257.376
• Mol file: 124286-84-6.mol

Synonyms:cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one

Chemical Property of cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one

There total 6 articles about cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate (124286-83-5) → cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one (124286-84-6)

Guidance literature:

With sulfuric acid; for 0.75h; Heating;

DOI:10.1021/jo00290a006

Reference yield:

1-(phenylmethyl)-3-ethyl-1,4,5,6-tetrahydropyridine (19716-82-6) → cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one (124286-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 31 percent / acetonitrile / 105 °C

2: methanol / Heating

3: 65 percent / t-BuOK / toluene / 12 h / 65 °C

4: 66 percent / 20percent H₂SO₄ / 0.75 h / Heating

With sulfuric acid; potassium tert-butylate; In methanol; toluene; acetonitrile;

DOI:10.1021/jo00290a006

Reference yield:

1,1-dimethylethyl (+/-)-6-ethyl-2-(phenylmethyl)-2-azabicyclo<4.2.0>octane-8-carboxylate (124286-80-2) → cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one (124286-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / Heating

2: 65 percent / t-BuOK / toluene / 12 h / 65 °C

3: 66 percent / 20percent H₂SO₄ / 0.75 h / Heating

With sulfuric acid; potassium tert-butylate; In methanol; toluene;

DOI:10.1021/jo00290a006

upstream raw materials:

1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate

1-(phenylmethyl)-3-ethyl-1,4,5,6-tetrahydropyridine

1,1-dimethylethyl (+/-)-6-ethyl-2-(phenylmethyl)-2-azabicyclo<4.2.0>octane-8-carboxylate

3-(1-Benzyl-3-ethyl-2-methoxy-piperidin-3-yl)-propionic acid tert-butyl ester

Downstream raw materials:

cis-(+/-)-1-(3-chlorophenyl)-7a-ethyl-6,7,7a,8,9,9b-hexahydro-3H-cyclopentaquinolizin-2(5H)-one

cis-(+/-)-1-(3-chlorophenyl)-3-(4'a-ethylhexahydrospiro<1,3-dioxolane-2,7'-<7H-1>pyrindin>-1'(2'H)-yl)-2-propanone

cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one ethylene ketal