1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate
• CAS No.: 124286-83-5
• Molecular Formula: C₂₂H₃₂N₂O₂
• Molecular Weight: 356.508
• Mol file: 124286-83-5.mol

Synonyms:1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate

Chemical Property of 1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate

There total 5 articles about 1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,1-dimethylethyl (+/-)-3-(2'-cyano-3'-ethyl-1'-(phenylmethyl)hexahydropyridin-3'-yl)propanoate (124286-79-9,124316-03-6) → 1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate (124286-83-5)

Guidance literature:

With potassium tert-butylate; In toluene; at 65 ℃; for 12h;

DOI:10.1021/jo00290a006

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) → 1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate (124286-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 31 percent / acetonitrile / 105 °C

2: methanol / Heating

3: 65 percent / t-BuOK / toluene / 12 h / 65 °C

With potassium tert-butylate; In methanol; toluene; acetonitrile;

DOI:10.1021/jo00290a006

Reference yield:

1-(phenylmethyl)-3-ethyl-1,4,5,6-tetrahydropyridine (19716-82-6) → 1,1-dimethylethyl cis (+/-)-7-amino-4a-ethyl-2,3,4,4a,5,7a-hexahydro-1-(phenylmethyl)-1H-1-pyrindine-6-carboxylate (124286-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 31 percent / acetonitrile / 105 °C

2: methanol / Heating

3: 65 percent / t-BuOK / toluene / 12 h / 65 °C

With potassium tert-butylate; In methanol; toluene; acetonitrile;

DOI:10.1021/jo00290a006

upstream raw materials:

1,1-dimethylethyl (+/-)-3-(2'-cyano-3'-ethyl-1'-(phenylmethyl)hexahydropyridin-3'-yl)propanoate

1-(phenylmethyl)-3-ethyl-1,4,5,6-tetrahydropyridine

tert-Butyl acrylate

1,1-dimethylethyl (+/-)-6-ethyl-2-(phenylmethyl)-2-azabicyclo<4.2.0>octane-8-carboxylate

Downstream raw materials:

cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one

(+/-)-4a-ethyloctahydro-8-(phenylmethyl)-2H-pyrano<2,3-b>pyridin-2-one

cis-(+/-)-4a-ethyloctahydro-1-(phenylmethyl)-7H-1-pyridin-7-one ethylene ketal

cis-(+/-)-1-(3-chlorophenyl)-7a-ethyl-6,7,7a,8,9,9b-hexahydro-3H-cyclopentaquinolizin-2(5H)-one