N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

Base Information

Chemical Name:N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine
CAS No.:917900-46-0
Molecular Formula:C₁₈H₁₉ClN₄
Molecular Weight:326.829
Hs Code.:

N<SUP>1</SUP>-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

Synonyms:N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

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Technology Process of N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

There total 4 articles about N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562421-27-5
C₁₆H₁₂Cl₂N₂

: 107-15-3,85404-18-8
ethylenediamine

: 917900-46-0
N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 140 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1016/j.ejmech.2013.11.036

Reference yield:

: 105901-10-8
1-((4-bromophenyl)-(4-chlorophenyl))methanol

: 917900-46-0
N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 6 h / 110 °C / Sealed tube

2: thionyl chloride / dichloromethane / 6 h / 0 - 25 °C

3: potassium carbonate; potassium iodide / acetonitrile / 0.33 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; potassium iodide; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.11.036

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 917900-46-0
N¹-((4-(1H-pyrazol-4-yl)phenyl)(4-chlorophenyl)methyl)ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 6 h / 110 °C / Sealed tube

3: thionyl chloride / dichloromethane / 6 h / 0 - 25 °C

4: potassium carbonate; potassium iodide / acetonitrile / 0.33 h / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.11.036