tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate

Base Information

Chemical Name:tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate
CAS No.:149325-45-1
Molecular Formula:C₂₀H₂₆N₄O₂
Molecular Weight:354.452
Hs Code.:

tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopenta<d>pyrimidin-5-yl)ethyl>benzoate

Synonyms:tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate

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Technology Process of tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate

There total 11 articles about tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 593-85-1,90332-86-8,3425-08-9
diguanidine carbonate

: 149325-44-0
tert-butyl 4-<2-(2-cyano-3-methoxy-2-cyclopentenyl)ethyl>benzoate

: 149325-45-1
tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate

Guidance literature:: In tert-butyl alcohol; at 160 ℃;
DOI:10.1021/jm00037a012

Reference yield:

: 65874-27-3
4-(tert-butoxycarbonyl)benzaldehyde

: 149325-45-1
tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-butyllithium / 1.) THF, hexane, 1 h, 2.) hexane, THF, 30 min

2: 1.) 9-BBN, 2.) aq. 6N NaOH, H₂O₂ / 1.) THF, RT, 2 h, 2.) THF, H₂O, RT, 1 h

3: triethylamine / CH₂Cl₂

4: NaI / acetone / Heating

5: tributyltin hydride, AIBN / benzene / Heating

6: 94 percent / N,N-diisopropylethylamine / hexane / Ambient temperature

7: 76 percent / 2-methyl-propan-2-ol / 160 °C

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In hexane; dichloromethane; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/jm00037a012

Reference yield:

: 91624-95-2
5-oxo-1-cyclopentene-1-carbonitrile

: 149325-45-1
tert-butyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethyl>benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: tributyltin hydride, AIBN / benzene / Heating

2: 94 percent / N,N-diisopropylethylamine / hexane / Ambient temperature

3: 76 percent / 2-methyl-propan-2-ol / 160 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; In hexane; tert-butyl alcohol; benzene;
DOI:10.1021/jm00037a012