1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine

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Chemical Name:1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine
CAS No.:1347759-28-7
Molecular Formula:C₂₃H₃₂N₄O₂Sn
Molecular Weight:515.243
Hs Code.:

Synonyms:1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine

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Chemical Property of 1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine

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Technology Process of 1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine

There total 8 articles about 1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1347759-27-6
3-iodo-1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-amine

: 661-69-8
hexamethyldistannane

: 1347759-28-7
1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine

Guidance literature:: trans-bis(triphenylphosphine)palladium dichloride; In toluene; at 110 ℃; for 15h; Inert atmosphere; Sealed tube;

Reference yield:

: 138642-40-7
methyl 2,4-dichloro-6-methylpyridine-3-carboxylate

: 1347759-28-7
1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C

1.2: -78 - 20 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

3.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

4.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

5.1: potassium hydroxide / N,N-dimethyl-formamide / 25 °C

6.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 170 °C / Microwave irradiation

7.1: trans-bis(triphenylphosphine)palladium dichloride / toluene / 15 h / 110 °C / Inert atmosphere; Sealed tube

With oxalyl dichloride; iodine; diisobutylaluminium hydride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; butan-1-ol;

Reference yield:

: 374800-25-6
2,4-Dichloro-3-hydroxymethyl-6-methylpyridine

: 1347759-28-7
1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

2: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

3: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

4: potassium hydroxide / N,N-dimethyl-formamide / 25 °C

5: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 170 °C / Microwave irradiation

6: trans-bis(triphenylphosphine)palladium dichloride / toluene / 15 h / 110 °C / Inert atmosphere; Sealed tube

With oxalyl dichloride; iodine; hydrazine hydrate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; butan-1-ol;