2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride

Base Information

Chemical Name:2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride
CAS No.:1456907-36-0
Molecular Formula:C₃₅H₃₆ClN₃O₂*ClH
Molecular Weight:602.604
Hs Code.:

Synonyms:2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride

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Chemical Property of 2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride

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Technology Process of 2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride

There total 7 articles about 2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1456906-73-2
6-O-methanesulfonyl-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

: (±)-trans-2-phenylcyclopropylamine

: 1456907-36-0
2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 24h;

Reference yield: 72.0%

: 1456906-73-2
6-O-methanesulfonyl-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

: 155-09-9
trans-2-phenylcyclopropylamine

: 1456907-36-0
2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/anie.201303999

Reference yield:

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 1456907-36-0
2-[N-(4-phenylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-(4-chlorobenzyl)hexanamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: piperidine / dichloromethane / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 2.5 h / 0 - 20 °C

5: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

6: pyridine / 0 - 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With piperidine; pyridine; hydrogenchloride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999