(2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide

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Chemical Name:(2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide
CAS No.:870773-66-3
Molecular Formula:C₂₅H₃₄F₂N₄O₅
Molecular Weight:508.566
Hs Code.:

Synonyms:(2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide

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Chemical Property of (2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide

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Technology Process of (2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide

There total 1 articles about (2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 690258-05-0
(2S,3S)-N-(tert-butoxycarbonyl)amino-2-(4-bromophenyl)-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide

: 616-45-5
2-pyrrolidinon

: 870773-66-3
(2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 100 ℃; for 72h;

Reference yield:

: 870773-66-3
(2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide

: (2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)cyclohexyl]butanamide

Guidance literature:: With hydrogen; acetic acid; platinum(IV) oxide; at 20 ℃; for 24h; under 2280.15 Torr;

Reference yield:

: 870773-66-3
(2S,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-(2-oxopyrrolidin-1-yl)phenyl]butanamide

: (2S,3S)-1-(3,3-difluoropyrrolidin-1-yl)-4-(dimethylamino)-1,4-dioxo-3-[4-(2-oxopyrrolidin-1-yl)cyclohexyl]butan-2-aminium trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; acetic acid / platinum(IV) oxide / 24 h / 20 °C / 2280.15 Torr

2: hydrogenchloride / diethyl ether / 1.25 h / 20 °C

With hydrogenchloride; hydrogen; acetic acid; platinum(IV) oxide; In diethyl ether;