Pyrimido[1,2-a]benzimidazole, 2,4-diphenyl-

Base Information

• Chemical Name: Pyrimido[1,2-a]benzimidazole, 2,4-diphenyl-
• CAS No.: 107553-43-5
• Molecular Formula: C22H15 N3
• Molecular Weight: 321.381
• Mol file: 107553-43-5.mol

Synonyms:Pyrimido[1,2-a]benzimidazole, 2,4-diphenyl-

Chemical Property of Pyrimido[1,2-a]benzimidazole, 2,4-diphenyl-

Chemical Property:

• PSA: 30.19000
• LogP: 5.21650

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimido[1,2-a]benzimidazole, 2,4-diphenyl-

There total 19 articles about Pyrimido[1,2-a]benzimidazole, 2,4-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(1H-benzimidazol-2-yl)-2,4,6-triphenylpyridinium perchlorate → 2,4-diphenylbenzimidazo<1,2-a>pyrimidine (107553-43-5)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 0.25h; Heating;

DOI:10.1135/cccc19921672

Reference yield: 89.0%

1H-benzimidazol-2-amine (934-32-7) + 2-(phenylsulfonyl)acetophenone (3406-03-9) + benzaldehyde (100-52-7) → 2,4-diphenylbenzimidazo<1,2-a>pyrimidine (107553-43-5)

Guidance literature:

In N,N-dimethyl-formamide; at 28 - 30 ℃; for 0.25h; regiospecific reaction; Sonication;

DOI:10.1016/j.ultsonch.2011.05.003

Reference yield: 84.0%

1H-benzimidazol-2-amine (934-32-7) + benzaldehyde (100-52-7) + phenylacetylene (536-74-3) → 2,4-diphenylbenzimidazo<1,2-a>pyrimidine (107553-43-5)

Guidance literature:

With copper(II) oxide; In neat (no solvent); at 100 ℃; Green chemistry;

DOI:10.1016/j.tetlet.2018.05.005

upstream raw materials:

1H-benzimidazol-2-amine

1,3-diphenylpropanedione

2,4,6-triphenylpyrylium tetrafluoroborate

3-dimethylamino-1,3-diphenyl-2-propen-1-one

Refernces

• 1、 Palaniraja, Jeyakannu,Roopan, Selvaraj Mohana,Rayalu, G. Mokesh,Al-Dhabi, Naif Abdullah,Arasu, Mariadhas Valan. "A metal-free regioselective multicomponent approach for the synthesis of free radical scavenging pyrimido-fused indazoles and their fluorescence studies". . . Retrieved 2016.
• 2、 Wu, Jiarong,Luo, Huan,Wang, Tao,Sun, Huaming,Zhang, Qi,Chai, Yonghai. "Diverse synthesis of pyrimido[1,2-a]benzimidazoles and imidazo[2,1-b]benzothiazoles via CuI-catalyzed decarboxylic multicomponent reactions of heterocyclic azoles, aldehydes and alkynecarboxylic acids". . p. 1052 - 1063. Retrieved 2019/01/25.